79 AD - Egypt - Long-term water storage900’s - China - Emperor used only silver eating “to prevent poisoning”.1100’s - Europe - Vatican mandate to use silver goblet s1880 – Crede’s prophylaxis for infant eye drops1920’s - Over 3 million prescriptions written annually for silver-containing medications1960’s – Silver compounds begin to be used in burn wards1970’s – Silver based applications reemerge2000’s – AgION antimicrobial used in “in body” medical devices